All games kick off at 8:15 p.m. ET and stream exclusively on Prime Video. Let’s go week by week:

Week 1 – Sept. 4

Dallas Cowboys @ Philadelphia Eagles Prediction: Cowboys will come away with the win, bringing the reigning champions to a 0-1 start.

Week 2 – Sept. 11

Washington Commanders @ Green Bay Packers Prediction: Washington squad will rise under the Lambeau lights leaving the home crowd in shock.

Week 3 – Sept. 18

Miami Dolphins @ Buffalo Bills Prediction: Bills win Josh Allen has dominated Miami historically, and with Joey Bosa anchoring the defense, Buffalo holds strong at home.

Week 4 – Sept. 25

Seattle Seahawks @ Arizona Cardinals Prediction: Seahawks win Seattle’s defense overwhelms Kyler Murray, and Geno Smith finds enough rhythm to steal a road win.

Week 5 – Oct. 2

San Francisco 49ers @ Los Angeles Rams Prediction: 49ers win This NFC West clash is always electric, but the Niners’ depth and coaching edge give them the nod.

Week 6 – Oct. 9

Philadelphia Eagles @ New York Giants Prediction: Daniel Jones will shine this year, delivering a surprise win over the Super Bowl Champs.

Week 7 – Oct. 16

Pittsburgh Steelers @ Cincinnati Bengals Prediction: Bengals win Joe Burrow thrives in primetime, and the Bengals’ offense proves too dynamic for Pittsburgh’s defense.

Week 8 – Oct. 23

Minnesota Vikings @ Los Angeles Chargers Prediction: Chargers win J.J. McCarthy faces his former college coach Jim Harbaugh, but Justin Herbert and the Bolts edge out a shootout.

Week 9 – Oct. 30

Baltimore Ravens @ Miami Dolphins Prediction: Ravens win Lamar Jackson’s mobility keeps Miami’s defense guessing, and Baltimore’s secondary locks down late.

Week 10 – Nov. 6

Las Vegas Raiders @ Denver Broncos Prediction: Broncos win Denver’s defense shines at home, and the Raiders struggle to find consistency on offense.

Week 11 – Nov. 13

New York Jets @ New England Patriots Prediction: Jets win, outdueling a young Patriots squad, and the Jets’ defense forces key turnovers.

Week 12 – Nov. 20

Buffalo Bills @ Houston Texans Prediction: Bills win A potential playoff preview, but Buffalo’s experience gives them the edge over C.J. Stroud’s Texans.

Week 13 – Nov. 28 (Black Friday)

Chicago Bears @ Philadelphia Eagles Prediction: Eagles win The Bears are improving, but Philly’s roster depth and home-field advantage prove too much.

Week 14 – Dec. 4

Dallas Cowboys @ Detroit Lions Prediction: Lions win Detroit’s offense is humming, and Ford Field is rocking as they take down “America’s Team.”

Week 15 – Dec. 11

Atlanta Falcons @ Tampa Bay Buccaneers Prediction: Buccaneers win A gritty NFC South battle, but Tampa’s defense makes the difference in a low-scoring affair.

Week 16 – Dec. 18

Los Angeles Rams @ Seattle Seahawks Prediction: Rams win Sean McVay schemes up a late-season win, and the Rams stay in the playoff hunt.

Week 17 – Dec. 25 (Christmas Day)

Denver Broncos @ Kansas City Chiefs Prediction: Chiefs win Patrick Mahomes delivers a holiday highlight reel, and Arrowhead celebrates with fireworks.

That’s the full ride through Thursday nights in 2025—packed with rivalries, redemption arcs, and playoff drama.